Cytotoxicity and mode of action of 5-azacytidine on L1210 leukemia.
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چکیده
2620 A Comparison of Some Ultrastructural and Biochemical Properties of Mitochondria from Morris Hepatomas 9618A, 7800, and 3924A. Peter L. Pederson, John W. Greenawalt, T. L. Chan, and Harold P. Morris. 2627 The Effect of 1-/3-D-Arabinofuranosylcytosine on Growth, Viability, and DNA Synthesis of Mouse L-cells. F. L. Graham and G. F. Whitmore. 2636 Studies in Mouse L-cells on the Incorporation of 1-/3-D-Arabinofuranosylcy tosine into DNA and on Inhibition of DNA Polymerase by 1-ß-D-Arabinofuranosylcytosine 5' -Triphos phate. F. L. Graham and G. F. Whitmore. 2645 Enhancement of Murine Sarcoma Virus (Moloney) Infection in Mice by Guaroa Virus. W. Turner, W. Gibson, and M. A. Chirigas. 2652 Inhibition of Thymidine Phosphorylation and DNA and Histone Synthesis in Ehrlich Ascites Carcinoma. Chi-Bom Chae, Ann Williams, Harvey Krasny, J. Logan Irvin, and Claude Piantadosi. 2661 Prevention of Gross Virus-induced Leukemia in Progeny of Immunized Female Rats. Harry L. Joachim.
منابع مشابه
Cytotoxicity and Mode of Action of 5-Azacytidine on LI 210 Leukemia1
This study attempts to determine the primary actions of 5-azacytidine (5-azaCR) on L1210 leukemia. This agent was cytotoxic toward L1210 cells growing in culture with 50 and 90% inhibition dose values of 0.019 and circa 0.15 jug/ml, respectively. 5-AzaCR inhibits the incorporation of tritiated thymidine or deoxyadenosine into DNA to a greater extent than it inhibits the incorporation of tritiat...
متن کاملComparative studies of the cytostatic action and metabolism of 5-azacytidine and 5,6-dihydro-5-azacytidine.
5,6-Dihydro-5-azacytidine hydrochloride, a chemically stable, soluble analog of 5-azacytidine, has cytostatic activity against mouse leukemic L1210 cells grown in culture, but concentrations on the order of 10 micronM, 10-fold higher, than the parent drug, are necessary to inhibit cell growth. The addition of either cytidine or uridine protected against growth inhibition by 5-azacytidine and 5,...
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1-[4-(2-Alkylaminoethoxy)phenylcarbonyl]-3,5-bis(arylidene)-4-piperidones are a novel class of potent cytotoxic agents. These compounds demonstrate low micromolar to submicromolar IC50 values against human Molt 4/C8 and CEM T-lymphocytes and murine leukemia L1210 cells. In this study, a comparative QSAR investigation was performed on a series of 3,5-bis(arylidene)-4-piperidones using different ...
متن کاملComparative QSAR Analysis of 3,5-bis (Arylidene)-4-Piperidone Derivatives: the Development of Predictive Cytotoxicity Models
1-[4-(2-Alkylaminoethoxy)phenylcarbonyl]-3,5-bis(arylidene)-4-piperidones are a novel class of potent cytotoxic agents. These compounds demonstrate low micromolar to submicromolar IC50 values against human Molt 4/C8 and CEM T-lymphocytes and murine leukemia L1210 cells. In this study, a comparative QSAR investigation was performed on a series of 3,5-bis(arylidene)-4-piperidones using different ...
متن کاملMetabolism and cytotoxicity of 5-azacytidine in cultured Novikoff rat hepatoma and P388 mouse leukemia cells and their enhancement by preincubation with pyrazofurin.
5-Azacytidine transport into cells was measured in the absence of metabolism in adenosine triphosphate-depleted and uridine kinase-deficient Novikoff cells. Azacytidine is transported with about the same efficiency as uridine and cytidine by the facilitated nucleoside transport system of these cells. The phosphorylation of azacytidine in untreated, wild-type cells, however, is much more inhibit...
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ورودعنوان ژورنال:
- Cancer research
دوره 30 11 شماره
صفحات -
تاریخ انتشار 1970